Pinealon

Pinealon

Pinealon (Glu-Asp-Arg tripeptide)

Russian neuroprotective sleep tripeptide

SleepCognitive ★ 55
Half-life
Not well characterized in published literature
Cycle
10-20 day cycles (extendable to 28 days), 2-3 cycles per year, with 2-3 months between cycles.
Storage
Lyophilized: -20°C long-term or 2-8°C short-term. Reconstituted: 2-8°C. Avoid freeze-thaw cycles.
Research
No large Western RCTs published. Evidence consists of Russian preclinical work in Alzheimer's models and a 72-patient TBI cohort study.

About

Pinealon is a synthetic Glu-Asp-Arg (EDR) tripeptide from the Khavinson bioregulator family, developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is proposed to enter cells and cross the nuclear membrane to bind gene promoter regions, influencing antioxidant and neurotrophic gene expression. The evidence base is dominated by Russian-language preclinical work and small clinical cohorts.

Mechanism

Proposed epigenetic regulation via direct binding to DNA promoter regions, modulating ERK 1/2 signaling and upregulating antioxidant and anti-apoptotic gene expression in neurons.

Dosage

1.0 mg
Once daily
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Draw to 15 units on a U-100 insulin syringe

20 mg · 3 mL BAC

Route
SubQ
Duration
5 days

When to take: Morning or early afternoon. Most subjective changes appear after 10-14 days of daily use.

Reconstitution

Vial size (mg): 20 mg · BAC water (mL): 3 mL · Concentration: ~6.67 mg/mL

1 unit on a U-100 syringe ≈ 66.7 mcg; swirl gently, do not shake. Oral capsule form also exists.

Benefits

  • Reported reduction of reactive oxygen species in neural cells
  • Restoration of dendritic spines in Alzheimer's animal models
  • Improvements in memory and mental clarity in small TBI cohorts
  • Reported sleep quality improvements (often first noticeable effect)
  • Possible mood and stress-resilience effects

Side effects

  • Mild headache early in cycle
  • Vivid dreams or altered sleep depth
  • Mild GI effects (oral route)
  • Injection-site redness or itching
  • Long-term safety unmapped in Western trials

Gender notes

Same dosing schedule. Some users pair with Epitalon for combined longevity protocol.

Cautions

  • Pregnancy and breastfeeding
  • Active or recent cancer history
  • Seizure disorders
  • Children and adolescents
  • Concurrent CNS prescription medications
  • Known peptide allergies

Research

Stacks well with

EpitalonSemaxSelankDSIPCerebrolysin
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