DSIP
Delta Sleep-Inducing Peptide
Deep sleep and delta waves
Sleep ★ 70
Half-life
Short (~7 min) but biological effects are sustained
Cycle
Can be used daily long-term but also cycled 4-6 weeks on, 1-2 weeks off.
Storage
Lyophilized: freezer. Reconstituted: 2-8°C, 30 days.
Research
Limited Western trials, strong anecdotal evidence
About
A naturally occurring peptide that promotes delta-wave sleep. Induces deep, restorative sleep.
Mechanism
Promotes delta-wave activity on EEG. Modulates the circadian rhythm.
Dosage
100 mcg
1x per day before sleep
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Draw to 5 units on a U-100 insulin syringe
5 mg · 2.5 mL BAC
Route
SubQ
Duration
As long as needed
When to take: 30 min before sleep.
Reconstitution
Vial size (mg): 5 mg · BAC water (mL): 2.5 mL · Concentration: 2 mg/mL
Low dose, so 2.5 mL is convenient.
Benefits
- Deep sleep (slow-wave sleep)
- Faster sleep onset
- Improved morning energy
- Stress reduction
- Possibly helpful for alcohol withdrawal
- No morning grogginess
Side effects
- Very well tolerated
- Rare: vivid dreams
Gender notes
Same dose. Popular for shift workers.
Cautions
- Pregnancy
- Other sleep medications (possible interaction)
Research
- Schneider-Helmert D: DSIP for sleep disorders
European Neurology · 1987
Clinical trial of DSIP for chronic insomnia.
- Graf MV, Kastin AJ: DSIP biological actions
Neuroscience & Biobehavioral Reviews · 1986
Review of DSIP's biological actions.