Sermorelin

Sermorelin

Sermorelin Acetate (GRF 1-29)

Classic GHRH analog — more natural GH pulse

Muscle GrowthAnti-Aging ★ 75 FDA Approved
Half-life
~10-20 minutes
Cycle
3-6 month cycles with 4-8 week breaks in between.
Storage
Lyophilized: refrigerated, 24+ months. Reconstituted: 2-8°C, 14 days (shorter than CJC-1295).
Research
FDA approved for pediatric GH deficiency, off-label for anti-aging

About

A 29-amino-acid GHRH analog, FDA approved since 1990 as Geref. The short half-life delivers a more natural GH pulse than CJC-1295. Popular in US anti-aging clinics.

Mechanism

Activates pituitary GHRH receptors, increasing endogenous GH production without overstimulation.

Dosage

100 mcg
1x per day before sleep
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Draw to 5 units on a U-100 insulin syringe

3 mg · 1.5 mL BAC

Route
Subcutaneous (SubQ)
Duration
8-12 weeks

When to take: Best before sleep (at least 2 hours after food) — the natural GH pulse is strongest then.

Reconstitution

Vial size (mg): 3 mg · BAC water (mL): 1.5 mL · Concentration: 2 mg/mL

Very fragile — handle gently, refrigerate immediately after reconstitution.

Benefits

  • More natural GH pulse than CJC-1295
  • Improved sleep depth
  • Increased muscle mass
  • Improved skin and hair
  • Milder side-effect profile

Side effects

  • Injection-site irritation
  • Headache (fresh dose)
  • Mild sleep disturbance in the first days
  • Possible nausea

Gender notes

Same dose. Popular after age 35.

Cautions

  • Active cancer
  • Pregnancy and breastfeeding
  • Diabetic retinopathy (consult physician)
  • Pituitary tumor

Research

Stacks well with

IpamorelinGHK-Cu
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