PT-141

PT-141

Bremelanotide (Vyleesi)

Sexual desire for both women and men

Sexual Health ★ 78 FDA Approved
Half-life
~2 hours
Cycle
On-demand. Not daily.
Storage
Lyophilized: cool. Reconstituted: 2-8°C, 4 weeks.
Research
FDA approved for HSDD (women). Off-label for men.

About

A melanocortin receptor agonist that acts on the brain to increase sexual desire — not the vascular system (unlike Viagra). FDA approved 2019.

Mechanism

Activates MC3R and MC4R receptors in the dopamine pathways of the brain that govern libido and arousal.

Dosage

500-750 mcg
On-demand, 45 min before activity
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Draw to 22.5 units on a U-100 insulin syringe

10 mg · 3 mL BAC

Route
SubQ
Duration
On-demand

When to take: 45 min - 4 hours before sex. Not on an empty stomach (worst nausea).

Reconstitution

Vial size (mg): 10 mg · BAC water (mL): 3 mL · Concentration: 3.33 mg/mL

Store refrigerated after reconstitution.

Benefits

  • Increases sexual desire (both sexes)
  • Helps with ED when PDE5 inhibitors do not work
  • Acts on the brain, not the vasculature
  • No need for visual stimulation

Side effects

  • Nausea (very common, 40%+)
  • Facial flushing
  • Transient blood pressure increase
  • Headache
  • Skin darkening with repeated use (rare)

Gender notes

Off-label use. 1-1.75 mg common. Sometimes stacked with tadalafil.

Cautions

  • Hypertension (uncontrolled)
  • Cardiovascular disease
  • Pregnancy

Research

Stacks well with

Kisspeptin-10
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