Kisspeptin-10

Kisspeptin-10

Kisspeptin-10 (Metastin 45-54)

GnRH stimulator — HPG axis activator

Sexual Health ★ 68
Half-life
~4 minutes (very short!)
Cycle
4-12 week cycles, with at least a 4-week break (to avoid desensitization).
Storage
Lyophilized: refrigerated. After reconstitution: 2-8°C, 7-14 days (shorter than most).
Research
Clinical trials underway for HSDD and hypogonadism

About

A 10-amino-acid peptide that activates Kiss1R receptors in the hypothalamus, the strongest natural activator of GnRH. Studied for hypogonadism and low testosterone.

Mechanism

Binds Kiss1R receptors on GnRH neurons, triggering an LH and FSH pulse and then testosterone or estradiol release.

Dosage

50 mcg
1x per day
0102030405060708090100

Draw to 5 units on a U-100 insulin syringe

5 mg · 5 mL BAC

Route
Subcutaneous (SubQ)
Duration
4-6 weeks

When to take: Best in the morning when natural hormone pulses are activating.

Reconstitution

Vial size (mg): 5 mg · BAC water (mL): 5 mL · Concentration: 1 mg/mL

A large bac volume yields convenient small doses. Very fragile — the peptide degrades quickly.

Benefits

  • Naturally raises LH and FSH
  • Improved libido (both sexes)
  • Raises testosterone (men)
  • Possible fertility boost
  • Gentler than HCG (no desensitization)

Side effects

  • Headache
  • Flushing and warmth
  • Rare: nausea
  • Well tolerated at low doses

Gender notes

Raises LH → testosterone. Popular as an HCG alternative.

Cautions

  • Hormone-sensitive cancers
  • Pregnancy
  • Pituitary tumor
  • Use of tamoxifen or aromatase inhibitors

Research

Stacks well with

PT-141
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