GHRP-2

GHRP-2

Growth Hormone Releasing Peptide-2 (Pralmorelin)

Classic GH releaser — stronger pulse than Ipamorelin

Muscle Growth ★ 70
Half-life
~15-60 minutes (SubQ)
Cycle
12-16 weeks on, 4-6 weeks off to reset receptors and stop prolactin creep.
Storage
Lyophilized: freezer. Reconstituted: 2-8°C, 28 days.
Research
Studied since the 1990s for GH deficiency, but never reached FDA approval. Widely used off-label.

About

A synthetic ghrelin receptor agonist that triggers strong GH release. More potent GH pulse than Ipamorelin but with side effects: elevated cortisol, prolactin, and intense hunger.

Mechanism

Binds GHS-R1a receptors in the pituitary to trigger GH release; also stimulates ghrelin's appetite pathway.

Dosage

100 mcg
1x per day before sleep
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Draw to 4 units on a U-100 insulin syringe

5 mg · 2 mL BAC

Route
Subcutaneous (SubQ)
Duration
8-12 weeks

When to take: Empty stomach, 30-60 min before food. Avoid sugar/carbs 30 min before to prevent GH blunting.

Reconstitution

Vial size (mg): 5 mg · BAC water (mL): 2 mL · Concentration: 2500 mcg/mL

Frequently stacked with CJC-1295 in the same syringe.

Benefits

  • Strong GH and IGF-1 elevation
  • Improved sleep depth
  • Muscle building
  • Cheaper than Ipamorelin
  • Useful for breaking lean-muscle plateaus

Side effects

  • Intense hunger surge (often within 30 min)
  • Elevated cortisol (transient stress)
  • Elevated prolactin (can affect libido long-term)
  • Water retention
  • Tingling in hands

Gender notes

Common dose 200-300 mcg, 2-3x daily. Watch for gyno from prolactin if running long cycles.

Cautions

  • Active cancer (hard contraindication)
  • Pregnancy and breastfeeding
  • Diabetes (monitor blood glucose)
  • Pituitary tumors
  • Hyperprolactinemia history

Research

Stacks well with

CJC-1295 (no DAC)IpamorelinBPC-157
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