CJC-1295 (no DAC)
Modified GRF 1-29
GHRH analog — amplifies the natural GH pulse
About
A synthetic GHRH (Growth Hormone Releasing Hormone) analog that activates pituitary GHRH receptors. Without DAC, the short half-life preserves natural pulsatility.
Mechanism
Binds GHRH receptors in pituitary somatotrophs, stimulating GH production and release.
Dosage
Draw to 4 units on a U-100 insulin syringe
5 mg · 2 mL BAC
When to take: Best on an empty stomach, 30-60 min before food or sleep. Almost always paired with Ipamorelin.
Reconstitution
Vial size (mg): 5 mg · BAC water (mL): 2 mL · Concentration: 2500 mcg/mL
Can be combined with Ipamorelin in the same syringe (same concentration).
Benefits
- Raises GH and IGF-1
- Muscle building
- Fat loss (especially visceral)
- Improved sleep
- Slower aging
- Improved energy and recovery
Side effects
- Facial flushing — transient
- Tingling
- Headache
- Fluid retention (rare)
Gender notes
Cautions
- Active cancer
- Pregnancy
- Pituitary disease
- Insulin resistance (caution)
Research
- Teichman SL et al: CJC-1295 sustained GH release
Journal of Clinical Endocrinology & Metabolism · 2006
Trial of CJC-1295 with and without DAC, showing sustained GH and IGF-1 elevation.
- Ionescu M, Frohman LA: CJC-1295 in healthy adults
Journal of Clinical Endocrinology & Metabolism · 2006
Clinical trial of CJC-1295 in healthy adults.