AOD-9604
Anti-Obesity Drug 9604 (HGH fragment 176-191)
HGH fragment — fat loss without GH side effects
About
A 16-amino-acid fragment of HGH that retains the fat-burning action of growth hormone without the muscle-growth or blood-sugar effects. Reached Phase 2b trials by Metabolic Pharmaceuticals.
Mechanism
Stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat storage) by activating β3-adrenergic receptors in adipocytes; does not affect IGF-1 or blood glucose.
Dosage
Draw to 10 units on a U-100 insulin syringe
5 mg · 2 mL BAC
When to take: Best on an empty stomach in the morning. Avoid food for 90 min after to maximize lipolysis.
Reconstitution
Vial size (mg): 5 mg · BAC water (mL): 2 mL · Concentration: 2500 mcg/mL
Standard reconstitution. Often stacked with GH secretagogues for synergistic fat loss.
Benefits
- Visceral and abdominal fat reduction
- No effect on blood glucose or insulin
- No effect on IGF-1 (safer for cancer history)
- Joint-friendly (unlike full GH)
- Well tolerated in clinical trials
Side effects
- Generally very mild
- Occasional injection-site irritation
- Mild fatigue first week
- No reported serious side effects in trials
Gender notes
Cautions
- Pregnancy and breastfeeding (limited data)
- Eating disorder history (caution with intentional fat loss)
Research
- Ng FM et al: Lipolytic and antilipogenic actions of HGH fragment 177-191
Hormone and Metabolic Research · 2000
Original characterization of the HGH 176-191 fragment's fat-burning mechanism.
- Heffernan M et al: AOD-9604 Phase 2 obesity trial
Diabetes, Obesity and Metabolism · 2007
12-week Phase 2 trial in obesity; modest but consistent fat loss without GH side effects.